The PFL 8 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 19, 2021. This was the second event for of the playoffs with the Heavyweight and Women's Lightweight divisions competing. This event aired on ESPN, with the prelims on ESPN+. Kayla Harrison, the only two-time Olympic gold medalist in judo in the history of the United States, entered her second PFL playoffs unbeaten in 10 pro bouts. She faced Genah Fabian who held a 4-1 record and had won both of her PFL regular season bouts against Julija Pajic and Laura Sanchez to advance to the playoffs.
Kayla Harrison
Genah Fabian
Bruno Cappelozza
Jamelle Jones
Taylor Guardado
Mariana Morais
Ante Delija
Denis Goltsov
Renan Ferreira
Stuart Austin
Muhammed DeReese
Carl Seumanutafa
Marina Mokhnatkina
Claudia Zamora
Amanda Leve
Miranda Barber
Christian Lohsen
Jonas Flok