The Team Rocket leader, Giovanni, has found Mewtwo in a remote area of the Johto region. As Giovanni tries to re-capture Mewtwo, Ash and his friends are kidnapped by Domino, a new Team Rocket member, while trying to rescue Pikachu from Jessie and James. The Clone Pokemon are also captured and are then used as bait for Mewtwo. The situation then becomes a battle between the wills of Mewtwo and Giovanni; and Mewtwo also tries to discover if it and the clones have a purpose in life, even though they are products of science.
Rica Matsumoto
Ikue Otani
Mayumi Izuka
Satomi Korogi
Yuji Ueda
Megumi Hayashibara
Shin-ichiro Miki
Inuko Inuyama
Masachika Ichimura
Hirotaka Suzuoki
Kotono Mitsuishi
Chinami Nishimura
Unsho Ishizuka
Aya Hisakawa
Yumi Touma
Rikiya Koyama