Peter Parker is going through a major identity crisis. Burned out from being Spider-Man, he decides to shelve his superhero alter ego, which leaves the city suffering in the wake of carnage left by the evil Doc Ock. In the meantime, Parker still can't act on his feelings for Mary Jane Watson, a girl he's loved since childhood. A certain anger begins to brew in his best friend Harry Osborn as well...
Tobey Maguire
Kirsten Dunst
James Franco
Alfred Molina
Rosemary Harris
J.K. Simmons
Donna Murphy
Daniel Gillies
Dylan Baker
Bill Nunn
Vanessa Ferlito
Aasif Mandvi
Willem Dafoe
Cliff Robertson
Ted Raimi
Elizabeth Banks
Bruce Campbell
Gregg Edelman
Elya Baskin
Mageina Tovah
Daniel Dae Kim
Hal Sparks
Joel McHale
Stan Lee
Kelly Connell
Brent Briscoe
Emily Deschanel
Jason Fiore-Ortiz
Scott Spiegel
Andy Bale
Christine Estabrook
Molly Cheek
John Paxton
Joy Bryant
Joanne Baron
Peter McRobbie
Timothy Jerome
Taylor Gilbert
Peter Vouras
Donnell Rawlings
Zachry Rogers
Ella Rogers
Louis Lombardi
Marc John Jefferies
Roshon Fegan
Brendan Patrick Connor
Reed Diamond
Dan Callahan
Elyse Dinh
John Landis
Tim Storms
Susie Park
Patricia M. Peters
Michael Edward Thomas
Anne Betancourt
Venus Lam
Bill E. Rogers
Joe Virzi
Tom Carey
Jopaul Van Epp
Weston Epp
Peter Allas
Brianna Brown
Bill Calvert
Tony Campisi
Joey Diaz
Chloe Dykstra
Simone Gordon
Dan Hicks
Julia Max
Savannah Pope
Timothy Patrick Quill
Jill Sayre
Rickey G. Williams
Michael Arthur
Frank Bonsangue
Cindy Cheung
Phil LaMarr
Andre M. Johnson
Peter Cincotti
Peyton List
Spencer List
Troy Metcalf
Scott Ross
Bonnie Somerville
Wesley Volcy
Lou Volpe
Garrett Warren
Joseph M. Caracciolo
David Boston
John Cameron
Sho Brown
Sal Ardisi
Edward Johnson
Grant Curtis
Vince Cupone
William E. Corcoran
Mohammed Hassan
Rachel Lehrer
Gene LeBell
Lorelei Llee
Joseph Nelson
Claudia Katz Minnick
Ronn Ozuk
Denney Pierce
Carla Rhodes
Randy Reinholz
Rachelle Roderick
Angel Katherine Taormina
Douglas Swander
Jimmy Star
Jack Wetherall
Ken Wharton
Henry Truong
Al Collado
Lee Cogburn
Sam Raimi