With the Gyaos re-emerging, Gamera's ties to humanity have been severed with his bond to Asagi broken. Nagamine and Asagi investigate while an orphaned girl named Ayana discovers a new creature she names Iris. Nagamine and Asagi must reach Ayana before she takes her revenge on Gamera, who she blames for the death of her family.
Ai Maeda
Shinobu Nakayama
Aki Maeda
Ayako Fujitani
Yû Koyama
Nozomi Ando
Ito Takahiro
Senri Yamazaki
Toru Tezuka
Yukijiro Hotaru
Hirotaro Honda
Kei Horie
Norito Yashima
Yūsuke Kawazu
Kunihiko Mitamura
Kazuko Kato
Nijiko Kiyokawa
Namase Katsuhisa
Aimi Takemura
Nikki Soraneko
Hiroyuki Watanabe
Hikaru Ijūin
Masahiro Noguchi
Tomoko Kawashima
Satoru Saito
Toshie Negishi
Tamotsu Ishibashi
Shôji Kôkami
Rita Kosegawa
Takaya Kamikawa
Tsuyoshi Shimada
Kenjirou Ishimaru
Masahiko Tsugawa
Osamu Shigematsu
Katsuko Nishina
Takashi Nishina
Tarou Oumiya
Ikkei Watanabe
Hitoshi Kusano
Ryoko Ozawa
Mika Takanishi
Shinobu Matsumoto
Miyuki Komatsu
Nanako Kaneko
Hirofumi Fukuzawa
Akira Ohashi
Asumi Miwa
Tomorowo Taguchi
Yukie Nakama