The major sub-plot circles around the youngest Griffin, Stewie, who has a near-death experience at a pool when a lifeguard chair falls on him, but he survives. After having a vision of being in Hell, he decides to change his ways, but this doesn't last long. While watching television, he and Brian spot a man that looks like Stewie. Brian is convinced that he is Stewie's real father, until Stewie learns that the man is actually himself as an adult, taking a vacation from his own time period. Baby Stewie visits thirty years later to discover that his adult self, going by the name Stu, is a single blue-collar middle-aged virgin working at a Circuit City-type store. Meanwhile, Peter and Lois are trying to teach their two older kids, Meg and Chris, to date. In the future, Chris, who hasn't changed much, is working as a cop and is married to a foul-mouthed hustler named Vanessa. Meg is now called Ron, since she had a sex-change after college.
Seth MacFarlane
Alex Borstein
Seth Green
Mila Kunis
Patrick Warburton
Lori Alan
Drew Barrymore
Mike Henry
Rachael MacFarlane
Noel Blanc
Phil LaMarr
John G. Brennan
Gary Janetti
Don LaFontaine
Ron Livingston
Kevin Michael Richardson
Kate Rigg
Will Sasso
André Sogliuzzo
Rory Thost
John Viener
Adam West
Wally Wingert
René Auberjonois
Ali Hillis
Ralph Garman
Jennie Garth
Larry Kenney
Lynne Lipton
Jason Priestley
Michael Clarke Duncan
Chris Sheridan
Danny Smith
Tori Spelling
Joy Behar
Fred Tatasciore
Adam Borstein
Bill Fagerbakke
David A. Goodman
Busy Philipps
Audrey Wasilewski