The PFL 6 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 25, 2021. This was the third regular season event of the tournament and included fights in the Heavyweight and women's Lightweight divisions. This event will aire on ESPN2, with the prelims on ESPN+. The event was headlined by Two-time Olympic gold medalist Kayla Harrison and Cindy Dandois.
Kayla Harrison
Cindy Dandois
Raush Manfio
Anthony Pettis
Bruno Cappelozza
Muhammed DeReese
Larissa Pacheco
Olena Kolesnyk
Ante Delija
Chandler Cole
Genah Fabian
Julija Pajić
Renan Ferreira
Carl Seumanutafa
Taylor Guardado
Laura Sanchez
Mariana Morais
Kaitlin Young
Jamelle Jones
Klidson Abreu