The Substance

If you follow the instructions, what could go wrong?

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Demi Moore

(Elisabeth)

Margaret Qualley

(Sue)

Dennis Quaid

(Harvey)

Edward Hamilton-Clark

(Fred)

Gore Abrams

(Oliver)

Oscar Lesage

(Troy)

Christian Erickson

(Man at Diner)

Robin Greer

(Male Nurse)

Tom Morton

(Doctor)

Hugo Diego Garcia

(Diego - Boyfriend)

Daniel Knight

(Casting Director)

Jonathon Carley

(Assistant Casting Director)

Jiselle Henderkott

(Girl Auditioning / New Year's Eve Show Dancer)

Akil Wingate

(TV Host)

Vincent Colombe

(Man in Suit #1 - Harvey's Office)

Billy Bentley

(Man in Suit #2)

Lennard Ridsdale

(Man in Suit #3)

Jordan Ford Silver

(Assistant Director - Pump It Up Show)

Oscar Salem

(2nd Assistant Director - Pump It Up Show)

Viviane Bossina

(Sue's Assistant)

Matthew Luret

(Floor Runner)

Jana Bittnerová

(Maria)

Olivier Raynal

(Alan - 2nd Agent)

Tiffany Hofstetter

(Stylist)

Nicolas Royer

(Guy in the Elevator)

Nathan Rippy

(Assistant Director - New Year's Eve Show)

Manon Arizmendi

(Little Girl - New Year's Eve Show)

Virginie Kotlinski

(Mother - New Year's Eve Show)

Brett Gillen

(Director of Photography - New Year's Eve Show)

Charlotte Marquardt

(Screaming Woman)

Léa Hengl

(Screaming Woman)

Gaëlle Raymond

(Screaming Woman)

Claire Lemaire

(Screaming Woman)

Lila Boughoufala

(Screaming Woman)

Aurélien Lorgnier

(Screaming Man)

Ivan Sellier

(Screaming Man)

Philip Schurer

(Screaming Man)

Christian Bourmier

(Shareholder)

Martin Graham

(Shareholder)

Christian Bordeleau

(Shareholder)

Patrick Hamel

(Shareholder)

Didier Dhondt

(Shareholder)

Jacques-Yves Dorges

(Shareholder)

Jean-Claude Matthey

(Shareholder)

Olivier Jarcin

(Shareholder)

Jean-Luc Magneron

(Shareholder)

Charlotte Murray

(Allison - Diner Waitress)

Aaron Kahn

(Greeting Person)

Gabriela Arnon

(Greeting Person)

Nancy Josephson Lahoussine

(Greeting Person)

Andrew Eldridge

(Greeting Person)

Denise Powers

(Greeting Person)

Bryan Jones

(Greeting Person)

Adam Carage

(Happy Birthday Person)

Maria McClurg

(Happy Birthday Person)

Andrew Desmond

(Happy Birthday Person)

Rebecca Lafont

(Happy Birthday Person)

Laura Puech

(Isabella)

Ryan Chidester

(Stagehand)

Céline Vogt

(Elisabeth (Young) - Walk of Fame)

Yannick Guérin

(Clumsy Burger Guy - Walk of Fame)

Jean Miel

(Worker Walk of Fame)

Paul Descoings

(Worker Walk of Fame)

Benoit Lévêque

(Worker Walk of Fame)

Arthur Molinet

(Cocktail Bartender)

Manon Sachot

(Cocktail Lounge Couple)

Bastien Jorelle

(Cocktail Lounge Couple)

Kelly Hoarau

(Female Assistant - Towel)

Michel Juskiewicz

(George - Harvey's Friend)

Louise Greggory

(Restaurant Waitress)

Christophe Sartirano

(Guy Looking at Sue)

Florent Torres

(Guy Looking at Sue)

Romain Caldeira

(Billboard Technician)

Barthelemy Thomas

(Billboard Technician)

Axel Baille

(Photographer)

Ashley Lambert

(Additional Voices (voice))

Ranjani Brow

(Additional Voices (voice))

Chase Fein

(Additional Voices (voice))

Shane Sweet

(Additional Voices (voice))

William Calvert

(Additional Voices (voice))

Michael Corbett

(Additional Voices (voice))

Stephen Apostolina

(Additional Voices (voice))

Yann Bean

(The Substance (voice))

Audjyan Alcide

(Pump It Up Show Dancer)

Jonathan Jenvrin

(Pump It Up Show Dancer)

Mimi Maury

(Pump It Up Show Dancer)

Amelye Solange

(Pump It Up Show Dancer)

Kévin Table

(Pump It Up Show Dancer)

Laura Boera

(Sparkle Your Life Show Dancer)

Cissy Duc

(Sparkle Your Life Show Dancer)

Sophie Mercier

(Sparkle Your Life Show Dancer)

Marie Valton

(Sparkle Your Life Show Dancer)

Katrina Budzynski

(New Year's Eve Show Dancer)

Alicia Maury

(New Year's Eve Show Dancer)

Megane Adamik

(New Year's Eve Show Dancer)

Annalisa Pagnotta

(New Year's Eve Show Dancer)

Maelle Dantigny

(New Year's Eve Show Dancer)

Aleksandra Fontaine Kedzierska

(New Year's Eve Show Dancer)

Pauline Sagetat

(New Year's Eve Show Dancer)

Agustina Fitzsimons

(New Year's Eve Show Dancer)

Elena Shcheglova

(New Year's Eve Show Dancer)

Eve Marchant

(New Year's Eve Show Dancer)

Lola Donati

(New Year's Eve Show Dancer)

Kate Matthews

(New Year's Eve Show Dancer)

Ophélie Jonard

(New Year's Eve Show Dancer)

Pauline Richard

(New Year's Eve Show Dancer)

Laureen Cappelliez

(New Year's Eve Show Dancer)

Daria Panchenko

(New Year's Eve Show Dancer)

Delphine Beaulieu

(New Year's Eve Show Dancer)

Victoria Brun

(New Year's Eve Show Dancer)

Cara Chapman

(New Year's Eve Show Dancer)

Katharine Matthews

(New Year's Eve Show Dancer)

Alexandra Faget

(New Year's Eve Show Dancer)

Clémence Juville

(New Year's Eve Show Dancer)

Margot L'Entete

(New Year's Eve Show Dancer)

Hillary Sukhonos

(New Year's Eve Show Dancer)

Matthew Géczy

(Bob Haswell (uncredited))

Namory Bakayoko

(Silhouette (uncredited))

Gregory Defleur

(Happy Birthday Person (uncredited))

Coralie Fargeat

((uncredited))